​ The Second Workshop to Non-Linear Mixed Effects Modeling using NONMEM for Beginners - 2015

*The University Hospital of Cologne* ​​ *The Second Workshop to Non-Linear Mixed Effects Modeling using NONMEM® for Beginners - 2015* After successfully having our first workshop last year, we are delighted to announce our 3-day “Second Workshop to Non-Linear Mixed Effects Modeling using NONMEM® for Beginners - 2015”. This workshop aims to introduce the basic concepts and principles of non-linear mixed effects modeling using NONMEM and other assisting software suites (e.g. PsN, Xpose & Pirana) to beginners with limited experience in pharmacokinetic/pharmacodynamic modeling. As part of the workshop, hands-on sessions and case studies will be offered to familiarize the participants with the workflow and technicalities associated with population modeling such as data management, model coding, and interpretation of the results. *Location*: The University Hospital of Cologne, Cologne Germany. *Date*: 3-5th October, 2015 *Instructors*: The course will be organized by the Clinical Pharmacology Unit in the University Hospital of Cologne, led by Prof. Uwe Fuhr, and tutored by Ahmed Suleiman, Sebastian Frechen and Max Taubert. The Clinical Pharmacology Unit at the University Hospital of Cologne has been active in the field of quantitative pharmacology and pharmacometrics for more than 10 years with significant contributions to the field. *Language*: English *Workshop Outline:* · Introduction to (non-)linear regression modeling: basic statistical principles, least squares and maximum likelihood fitting, fixed and random effects, first order (conditional) estimation. · Introduction to population pharmacokinetic modeling: introduction to NONMEM files (control stream and data file), structural model development, random effects modeling. · Model evaluation: introduction to supporting software tools (e.g. R, Xpose, PsN), goodness-of-fit plots, residual diagnostics, bootstrapping analysis, simulation based diagnostics (e.g. visual predictive checks). · Covariate model building · Introduction to modeling pharmacodynamics: different pharmacodynamic models, linking pharmacokinetics to pharmacodynamics *Workshop Fees* · 1240€ for participants from industry and commercial enterprises ​.​ · 525€ for academics and participants from non-profit organizations. · 238€ for students in MSc or PhD programs. Computers will *not* be provided and therefore we kindly ask you to bring your own laptops with you and we will provide the necessary software on USB sticks. Quoting some of the feedback from last year’s workshop: *“Instructors were experienced and well-informed. They were also patient with questions”* *“What I really liked about this workshop was the hands-on sessions”* *“Material was excellent, and the tutors made an excellent introduction to NONMEM”.* *For registration*: please send an e-mail to “ahmed_DOT_suleiman_AT_uk-koeln_DOT_de”; instructions for payment and participation confirmation will follow. Please *DO NOT* make any travel arrangements before we send you back a confirmation. Best Regards, -- ​Ahmed Abbas Suleiman Institute of Pharmacology - Clinical Pharmacology Unit The University Hospital of Cologne Gleueler Str. 24, 50931 Cologne, Germany Phone: +49-221-478-3402 e-mail: [email protected] <[email protected]> http://pharmakologie.uk-koeln.de/ <[email protected]>