Re: Guidence regarding scm
Dear Muhammad,
The time_varying option is described on pages 8-9 in the scm
userguide, see http://psn.sourceforge.net/pdfdocs/scm_userguide.pdf
. Flagging a covariate as time varying will affect the computation
of the median value of that covariate, and hence the centering of
that covariate and the break-point of the hockey-stick
parameterization. If the values of CRCL at different time points for
the same individual do not differ much from each other, or if you do
not use parameterizations where the median is important, then you
can ignore the warning.
If you have further questions regarding scm, I suggest you post them
on the PsN-general mailing list. To subscribe please go to
http://psn.sourceforge.net/list.php .
Best regards,
Kajsa
On 06/01/2015 11:12 AM, Muhammad Usman
wrote:
Dear NMUsers,
I am using AGE, CRCL and Body weight as continuous
covariates and Gender as categorical covariate for scm. When I
start scm by using PsN the scm starts but there is a warning
message stating "Warning: Individuals were found to have
multiple values in the CRCL column, but CRCL was not set as
time varying in the configuration file. Results may not be as
expected". In my data file the values for CRCL are not similar
for all the samples of few patients because there is a time
difference of almost 72 hours between 1st and last sample.
Can someone guide me is this a normal Situation or should I
define CRCL in time_varying command in my configuration file.
If so how can i write this command in configuration file....?
Waiting for Kind suggestions....
regards
--
Muhammad Usman
PhD Scholar
Westfälische Wilhelms-Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
- Klinische Pharmazie -
Corrensstrasse 48
48149 Münster
Room No. A120.209
Phone: +49 251/8332171
Mob # +49 176 70962067
--
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Kajsa Harling, PhD
System Developer
Department of Pharmaceutical Biosciences
Uppsala University
[email protected]
+46-(0)18-471 4308
http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/