PFIM Interface 4.0 is released!

Dear Nonmem users, The PFIM group ([email protected] <mailto:[email protected]>), would like to inform you that we have released PFIM Interface 4.0, the new version of the PFIM graphical user Interface. It can easily be downloaded on the internet site http://www.pfim.biostat.fr/. PFIM Interface 4.0 incorporates several new features based on the R script program of PFIM 4.0 and they are listed below: ·For population designs, optimisation can be performed with fixed parameters or fixed sampling times. ·The Fisher information matrix obtained after evaluation or optimisation can be saved in a file. ·Additional features for Bayesian designs are now available. The Bayesian Fisher information matrix has been implemented. Design for maximum a posteriori estimation of individual parameters can be evaluated or optimised and the predicted shrinkage is also reported. ·A new way has been added to specify user-defined models through an R function. ·It is now possible to visualise the graphs of the model and the sensitivity functions without performing evaluation or optimisation. Together with the new Interface we also release the User Guide for PFIM Interface 4.0. It includes detailed descriptions of all the features available in PFIM Interface, from the basics to the most recent and advanced ones. The “Use” section will take you through the new Interface and a series of examples, covering most possible features, is also provided. The User Guide of PFIM Interface 4.0 goes automatically inside the directory of PFIM Interface 4.0, but it can also be separately downloaded in the Documentation section at the usual internet site http://www.pfim.biostat.fr/. Best regards, on behalf of the PFIM group Giulia Lestini PhD student IAME UMR-S 1137, INSERM and Université Paris Diderot 16 rue Henri Huchard 75018 Paris, France tel: 33 (0) 1 57 27 75 40 email : [email protected]