New error message

From: Fisher Dennis Date: April 16, 2015 technical Source: mail-archive.com
Colleagues Running NONMEM 7.3 in OS X, I just encountered the following message: 0THE INPUT MATRIX IS SINGULAR. SOME OF THE DIAGONAL ELEMENTS OF THE UPPER TRIANGULAR MATRIX U OF THE LU FACTORIZATION ARE CLOSE TO ZERO. Of note, a Google search yields a hit to Bill Bachman’s reply to an email that I sent to this user group in 2010 (but no explanation) Can anyone explain the message? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com http://www.plessthan.com/