Cross-validation script in NM
Dear nm-users,
I'm trying to construct a NONMEM control file to be used in a cross-validation
study.
In a first problem statement I run an estimation step on a subset of my data.
In a subsequent problem statement (within the same control file) I am trying to
predict the PK of the subset that was not included in part 1.
I managed to do this by use of the MSFO option (in the first part of the
control file) and the $MSFI in de second part.
However, it appears that time-varying covariates (defined under $PK in the
first problem statement) are not evaluated when performing the predictions for
the second problem statement.
Does anyone know of a workaround for this or is there another way of combining
a fit and predict action (both on different data) within the same control-file?
Kind regards,
Pieter
--
Pieter Colin, Pharm.D., Ph.D.
Post-Doctoral researcher
(Faculty of Pharmaceutical Sciences - Ghent University)
Associate Professor
(Department of Anesthesiology - UMCG)