Cross-validation script in NM

From: Pieter Colin Date: December 04, 2014 technical Source: mail-archive.com
Dear nm-users, I'm trying to construct a NONMEM control file to be used in a cross-validation study. In a first problem statement I run an estimation step on a subset of my data. In a subsequent problem statement (within the same control file) I am trying to predict the PK of the subset that was not included in part 1. I managed to do this by use of the MSFO option (in the first part of the control file) and the $MSFI in de second part. However, it appears that time-varying covariates (defined under $PK in the first problem statement) are not evaluated when performing the predictions for the second problem statement. Does anyone know of a workaround for this or is there another way of combining a fit and predict action (both on different data) within the same control-file? Kind regards, Pieter -- Pieter Colin, Pharm.D., Ph.D. Post-Doctoral researcher (Faculty of Pharmaceutical Sciences - Ghent University) Associate Professor (Department of Anesthesiology - UMCG)
Dec 04, 2014 Pieter Colin Cross-validation script in NM
Dec 05, 2014 Kajsa Harling Re: Cross-validation script in NM
Dec 05, 2014 Pieter Colin RE: Cross-validation script in NM
Dec 05, 2014 Ron Keizer Re: Cross-validation script in NM
Dec 06, 2014 Alison Boeckmann Re: Cross-validation script in NM