Warning: PARAMETER ESTIMATE IS NEAR ITS BOUNDARY
Dear nmusers,
I have a trouble in solving this warning error despite of going through all
old post in this forum.
I have used the initial estimates from WINONLIN parameter estimates,
Tried median and means as initial estimates (IEs).
$EST METHOD=1 INTERACTION PRINT=5 MAX=9999 SIG=3 POSTHOC
MSFO=1cm_mixture.msf NOABORT
As mentioned earlier by Tom Ludden & Scot Van Wart, I have tried everything
they suggested, but still no luck
$EST METHOD=CONDITIONAL INTER MAXEVAL=9999 PRINT=5 NOTHETABOUNDTEST
NOOMEGABOUNDTEST NOSIGMABOUNDTEST
1. I have tried the initial estimates of the last run as initial estimate
for the next run
2. I have changed the initial estimates around the IEs from winonlin run.
3. I have changed the upper bounds, omega block (several times)
I appreciate your suggestions, thank you very much in advance.
Regards,
Shankar Lanke Ph.D.
$PK
IF (MIXNUM.EQ.1)THEN
TVCL=THETA(1)
CL=TVCL*EXP(ETA(1))
ELSE
TVCL=THETA(2)
CL=TVCL*EXP(ETA(2))
ENDIF
IF (MIXNUM.EQ.1)THEN
TVV=THETA(3)
V=TVV*EXP(ETA(3))
ELSE
TVV=THETA(4)
V=TVV*EXP(ETA(4))
ENDIF
S1=V
$MIX
NSPOP=2
P(1)=THETA(5)
P(2)=1-P(1)
$ERROR
DEL=0
IF (F.LE.0.0001) DEL=1
IPRE=F
W= IPRE +DEL
IRES= DV-IPRE
IWRE=IRES/W
Y = F + W*ERR(1)
$EST METHOD=CONDITIONAL INTERACTION PRINT=5 MAX=9999 NOTHETABOUNDTEST
NOOMEGABOUNDTEST NOSIGMABOUNDTEST SIG=3 POSTHOC MSFO=1cm_mixture.msf NOABORT
$THETA
(0,22,1000);[CL MIXNUM-1]
(0,105,1000);[CL MIXNUM-2]
(0,20,1000);[V MIXNUM-1]
(0,44,1000);[V MIXNUM-2]
(0,0.5,1) ;[MIXEST]
$OMEGA
0.0279 ;[P] omega(1,1)S
0.1 ;[P] omega(2,2)
0.1 ;
0.1 ;
0.1 ;
$SIGMA
0.0755 ;[A] sigma(1,1)