CHDR: Introduction course to Population PK and PK/PD modeling with NONMEM

Centre for Human Drug Research: Introduction course to Population PK and PK/PD modeling with NONMEM This hands-on course is an introduction to population modeling for analyzing pharmacokinetic and pharmacodynamic data and discusses the general concept of population modeling and the application in drug development. It includes a series of hands-on examples, which enables the attendees to learn to work with NONMEM and R to solve standard pharmacokinetic and pharmacodynamic problems, including data file preparation, model coding, and visualization/interpretation of the results. Target Audience The course is intended for people who have basic knowledge of PK/PD concepts and data analysis and wish to apply/extend their knowledge and skills on pharmacokinetics and pharmacodynamics in drug development. Course Objectives Aim of the course is to familiarize the participants with basics of population PK/PD modeling and to train the participants in working with NONMEM (Non Linear Mixed Effects Modeling) to conduct population PK and PK/PD data analyses. Details Instructor Dr. Jasper Stevens ([email protected]) Duration 3 x 8 hours Dates 29th to 31st of October, 2014; 9:00 – 17:00 hr (CET) Location CHDR, Zernikedreef 8, 2333 CL, Leiden, the Netherlands (T: +31 71 5246 400) Language English Maximum capacity 16 attendees Program Session 1 Agenda and brief introduction to population PK modeling, NONMEM and R Session 2 NONMEM work flow for population PK models (data management, data exploration, model code and execution, output and interpretation) Session 3 Population PK models continued: alternative administration routes, solving differential equations using NONMEM and simulations Session 4 Population PK/PD models: brief introduction to PK/PD models and implementation of direct effect models in NONMEM Session 5 Population PK/PD models continued: effect compartment and indirect response models Course fee The course fee is 1550 EUR, including course materials, coffee breaks, lunches and one evening dinner (Wednesday evening). Computers are available, including the required software packages. A limited number of students can register for a reduced fee (775 EUR), for which a support letter of the supervisor has to be included upon registration. Cancellation received before September 1st, 2014 is subject to full refund, cancellation received after this date is subject to 50% refund. Registration You can register by sending an email to [email protected] thereby including your name, affiliation and postal address. Jasper Stevens Pharmacometrician Centre for Human Drug Research Zernikedreef 8 2333 CL Leiden The Netherlands T +31 (0)71 5246462 F +31 (0)71 5246499 [email protected] http://www.chdr.nl Follow us: