RE: NONMEM vs SPSS
Dear Gavin,
Perhaps an idea is to compare the different MATRIX options of the covariance
step of NONMEM, and with the bootstrap, to assess their relative properties.
Erik
Quoted reply history
________________________________
From: [email protected] [[email protected]] on behalf of
Gavin Jarvis [[email protected]]
Sent: Saturday, March 29, 2014 5:55 PM
To: [email protected]
Subject: [NMusers] NONMEM vs SPSS
Dear NONMEM Users
Does anyone have a view on the relative merits/reliability/accuracy of NONMEM
($COV step) vs SPSS (NLR) with respect to their derived values of the parameter
standard errors and parameter correlation matrices?
The data I am analysing are single subject (not population). Parameter
estimates from the two programs are, to all intents and purposes, identical.
However, the SE values from NONMEM $COV are consistently smaller by
1.5-2.0-fold.
Any thoughts?
Gavin
__________________________________________________
Dr Gavin E Jarvis MA PhD VetMB MRCVS
University Lecturer in Veterinary Anatomy
Department of Physiology, Development & Neuroscience
Physiological Laboratory
Downing Street
Cambridge
CB2 3EG
Tel: +44 (0) 1223 333745
Fellow and College Lecturer in Pharmacology
Selwyn College
Cambridge
CB3 9DQ
Tel: +44 (0) 1223 761303
Email: [email protected]<mailto:[email protected]>
Web: http://www.pdn.cam.ac.uk/staff/jarvis
Twit: @GavinEJarvis