RE: NONMEM 7.2 and Pirana/Xpose4
Thank you for the response. I just copied the most recent control stream I had
which had the sdtab file labelled as sdtab104 instead of sdtab101 I initially
used in describing the problem. Regardless of the number extension on the sdtab
file it is not populated with any data; it is completely blank. I have tried
exploring all the GOF plot options in Pirana and have not been successful in
creating a single one. After some research I learned that Xpose4 uses the sdtab
file which is why I have concentrated on figuring out why it is not created. In
my group of at least 4 other people using NONMEM 7.2, Pirana, and Xpose4 no one
has been able to create the GOF plots or a populated sdtab file. Another person
using NONMEM 7 appears to have had no problem creating the plots withina n the
Pirana/Xpose environment. Is this an incompatiability with Pirana/Xpose4 and
NONMEM 7.2; and if so, is there a workaround?
Maggie
Quoted reply history
From: Mukul Minocha [mailto:[email protected]]
Sent: Friday, July 05, 2013 11:32 AM
To: Thomson, Maggie
Cc: [email protected]
Subject: Re: [NMusers] NONMEM 7.2 and Pirana/Xpose4
Hi Maggie,
The $TABLE code seems correct. However, I would like to point out you mentioned
sdtab101 in the text while the code has sdtab104. Also in Pirana, you just need
to highlight the model, the right hand side panel will give you several options
under SCRIPTS for basic GOF plots. Also, my suggestion to you would be to table
out all the continuous and categorical covariates in a separate $TABLE files
for plotting purposes. Following is an example that works well for me and what
I routinely use for my runs.
$TABLE ID TIME DV EVID NTIME OCC IPRED IWRES CWRES ONEHEADER NOPRINT
FILE=sdtab005
$TABLE ID TIME KA V CL IIVKA IIVV IIVCL ONEHEADER NOPRINT FILE=patab005
$TABLE ID TIME AGE WT CRCL ONEHEADER NOPRINT FILE=cotab005
$TABLE ID TIME ISM RACE ONEHEADER NOPRINT FILE=catab005
See that Pirana requires these standard notations for continuous (cotab) and
categorical (catab) covariates.
Hope this helps,
Mukul Minocha
Research scientist
CTM,
University of Maryland Baltimore
On Fri, Jul 5, 2013 at 11:24 AM, Thomson, Maggie
<[email protected]<mailto:[email protected]>> wrote:
I am new to NONMEM 7.2 and am having some issues generating the goodness of fit
plots within Pirana or Xpose through the R console. I believe the problem is
that the sdtab101 table is not created. When I try to open this file it is
completely blank. I am having this problem both with a practice dataset as well
as my own dataset. Below you will find the code that I am using to create the
sdtab file. I appreciate any help so that I can continue analyzing my data.
$TABLE ID TIME DV IPRED PRED IWRES CWRES WRES NOPRINT ONEHEADER FILE=sdtab104
Margaret Thomson, PharmD
PhD Candidate
University of Tennessee Health Science Center
--
-Mukul