Re: Covariance matrix of parameter estimates (standard errors)
JO,
*IF* NONMEM is able to complete the covariance step then the relative standard errors are included in the WFN nmgosim output file.
You will not find the RSE values if a) you did not include $COV in the control stream or b) NONMEM failed in the covariance step.
You can test nmgosim with WFN by running:
nmgosim theopd_gosim theopd_gest 1 5
in the WFN run directory. You will find all the parameters and their RSE values in run\theopd_goest.reg\theopd_goest.smy
Usually there is little interest in calculating these asymptotic RSE values because the parametric bootstrap performed by nmgosim gives more reliable estimates of the RSE and confidence intervals of parameters.
Nick
Quoted reply history
On 12/07/2013 10:09 p.m., NIYI ADEDOKUN wrote:
> Dear All,
>
> Is there a simple way to include the standard errors of parameter estimates (as found in the .cov file) in an output table following sequential simulation and estimation in NONMEM? On a related note, the NMGOSIM command in Wings for NONMEM does not appear to include the .cov file in its output - is there a workaround such that the standard errors of estimates (e.g. SETHET) can be included in the summary file?
>
> Kind regards,
> JO
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