Modelling and Simulation Opportunity at AstraZeneca (Oncology)

http://jobs.astrazeneca.com/jobs/22359-associateprincipal-scientist-pkpd-modelling-amp-simulation-oncology At AstraZeneca, our aim is to tackle illness and disease as effectively as possible. Through our R&D pipeline of life-changing medicines, we’re able to offer hope to millions around the world. And innovation is essential to our job. Our strategy includes a substantial application of Predictive Sciences, which help us to deliver drugs that tackle illness and disease even more effectively. The model-based approach is applied to the whole drug development process, and this includes providing Modelling & Simulation to deliver a quantitative understanding of the biological hypothesis of drug action on disease target. A pre-clinical quantitative pharmacology understanding underpins our human predictions of dose, dose schedule and therapeutic index and these predictions are critical to drug projects. The Oncology Innovative Medicines unit (iMED) has an exciting opportunity for an experienced Modelling & Simulation (M&S) scientist to join a vibrant global team. The individual will be embedded into the Oncology research group, working closely with scientists in Biology, Translation, Safety and other modellers. The successful candidate will have excellent problem solving, organizational and documentation skills, and strong oral and written communication skills. This role requires the ability to thrive in a team-based, multidisciplinary, fast-paced research environment. Minimum Requirements - Education and Experience ▪ PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, or applied mathematics, with at least 5 years of relevant industry experience in Modelling & Simulation, ideally in preclinical/translational setting, or an MS degree with at least 10 years of relevant industry experience. ▪ Experience in project-facing role at pharmaceutical R&D. ▪ Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development. ▪ Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost. ▪ Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP. -------------------------------------------------------------------------- AstraZeneca UK Limited is a company incorporated in England and Wales with registered number: 03674842 and a registered office at 2 Kingdom Street, London, W2 6BD. Confidentiality Notice: This message is private and may contain confidential, proprietary and legally privileged information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorised use or disclosure of the contents of this message is not permitted and may be unlawful. Disclaimer: Email messages may be subject to delays, interception, non-delivery and unauthorised alterations. Therefore, information expressed in this message is not given or endorsed by AstraZeneca UK Limited unless otherwise notified by an authorised representative independent of this message. No contractual relationship is created by this message by any person unless specifically indicated by agreement in writing other than email. Monitoring: AstraZeneca UK Limited may monitor email traffic data and content for the purposes of the prevention and detection of crime, ensuring the security of our computer systems and checking Compliance with our Code of Conduct and Policies.