Bootstrap, re-using inital model run results

From: Jpm Lommerse Date: February 14, 2013 technical Source: mail-archive.com
Hi I would like to ask to NONMEM community whether it is possible to re-use the results of a nonmem model run when starting bootstrapping. As I understand, a bootstrap run using PsN starts with a single calculation of the model of interest and data set as is. Once this initial model run has completed, the actual bootstrapping starts by sampling from the initial data set to the requested number of samples. However, the initial run often has been carried out already, and the bootstrap method this seems to be repeated. I am dealing with a rather time consuming model / data set. Therefore I was wondering whether it is possible the re-use the results of a nonmem model run and start the bootstrapping directly without repeating this initial nonmem model run. I was not able to find any option to do so. Perhaps there is way around? Thanks, Jos Jos Lommerse Assoc. Prin. Scientist, Quant. Sciences Clinical PK-PD T: +31 412 661456 F: +31 412 662555 [email protected]<mailto:[email protected]> MSD Molenstraat 110, 5342 CC Oss PO Box 20, 5340 BH Oss The Netherlands Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.
Feb 14, 2013 Jpm Lommerse Bootstrap, re-using inital model run results
Feb 14, 2013 Jpm Lommerse Bootstrap, re-using inital model run results
Feb 14, 2013 Pascal Girard RE: Bootstrap, re-using inital model run results
Feb 14, 2013 Mats Karlsson RE: Bootstrap, re-using inital model run results
Feb 14, 2013 Anubha Gupta RE: Bootstrap, re-using inital model run results
Feb 14, 2013 Pascal Girard RE: Bootstrap, re-using inital model run results