FW: Intersubject Variability in Logistic Regression

> From: Garimella, Tushar > Sent: Friday, January 25, 2013 3:43 PM > Subject: Intersubject Variability in Logistic Regression > > Dear NONMEM-users, > > We are working on a logistic regression problem using a dichotomous response > (1 observation per subject, either 0 or 1) and came across the following > control stream in the NM Users Guide: > > $PROB DICHOTOMOUS RESPONSE > $DATA data > $INPUT ID DOSE DV > $PRED > LOGIT=THETA(1)+THETA(2)*DOSE**THETA(3)+ETA(1) > A=EXP(LOGIT) > P=A/(1+A) > IF (DV.EQ.1) THEN > Y=P > ELSE > Y=1-P > ENDIF > $THETA .1 (25,100) (1,3,5) > $OMEGA 1 > $ESTIMATION MET=COND LAPLACE LIKE MAX=500 > $SCAT ETA(1) VS DOSE > > We are discussing the role and interpretation of the ETA as shown in the > control stream in the context of logistic regression (for example: is it > appropriate to estimate intersubject variability in logistic regression, and > how can this be interpreted with dichotomous data) and would like to seek > input from the group. > > Thank you in advance for your help > > Best regards, > > Tushar > > >