NMusers: Population PK model dose in mg/m2

Dear nmusers, We are working on developing a population PK model for a drug which is given intravenously. The drug dose is administered as mg/m2. I would like to know from the esteemed members if we can input the dose as mg/m2 in the data set for NONMEM. Since we do not have Body Surface Area (BSA) information for all the patients, please let us know if we can use mg/m2 as the dose units. We have both day 1 and day 5 (steady state) concentrations in patients for this compound. Please let us know that for developing the population PK model, whether we should use day 1 or day 5 or both concentration data set. Inputs from the experts will be highly appreciated. Thanks Tausif Tausif Ahmed, Ph.D. Asst. Director, Translational Research, Piramal Healthcare Limited, 1, Nirlon Complex, off Western Express Highway, Goregaon (East), Mumbai-400063 Email: [email protected]