RE: capecitabine PopPK
Dear Markus,
ID=10 is perhaps causing some trouble, leading to large omega^2, and perhaps
bias. How does the model work when you leave ID=10 out, at least temporarily,
and with FOCE?
Best regards,
Erik
Quoted reply history
________________________________________
From: [email protected] [[email protected]] on behalf of
markus joerger [[email protected]]
Sent: Saturday, December 15, 2012 9:24 AM
To: NONMEM
Subject: [NMusers] capecitabine PopPK
dear NMUSERS,
I am presently working on a capecitabine model (n=12, increasing levels of
liver dysfunction, 3 with additional renal dysfunction).
While the model works in FO, early capecitabine-concentration estimates are too
low, and this does not improve with adding a peripheral
compartment for capecitabine.
May some of the esteemed readers suggest how to improve the model for the
parent compound's early time-points?
thanks so much and best regards!
--
Markus Joerger MD-PhD
Department of Medical Oncology&Hematology
Clinical Trial Unit
Cantonal Hospital
St. Gallen
Switzerland
[email protected]<mailto:[email protected]>
[email protected]<mailto:[email protected]>
Phone: +41-765591070
Fax: +41-714946325