CPT: Pharmacometrics and Systems Pharmacology Now Live

The American Society for Clinical Pharmacology and Therapeutics (ASCPT) is pleased to announce the official launch of CPT: Pharmacometrics and Systems Pharmacology, the newest journal in the ASCPT family of journals, with the first papers to publish in the Journal now available online at www.nature.com/psp. Original Research papers included in the official launch are: ・ Bridging Clinical Outcomes of Canakinumab Treatment in Rheumatoid Arthritis Patients with a Population Model of IL-1β Kinetics ・ Modeling inter-individual variability in physiologically-based pharmacokinetics and its link to mechanistic covariate modeling ・ A PBPK Model to Predict Disposition of CYP3A-metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction ・ A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics ・ Pharmacokinetic-Pharmacodynamic Modeling of Severity Levels of Extrapyramidal Side Effects with Markov Elements Also included in the launch is an introductory Editorial by Piet van der Graaf, PhD, PharmD, Editor-in-Chief of CPT:PSP, discussing the importance of pharmacometrics and systems pharmacology in drug development and how CPT:PSP will contribute to the further growth of these disciplines and a broader application and better integration of model-based approaches across the R&D spectrum. Morna Conway, PhD, provides a Perspective on Open Access as the new model for publishing in the pharmacological sciences. And in Tutorial C a paper category created by CPT:PSP to offer readers practical tutorials on tools, methodologies and approaches in pharmacometrics and systems pharmacologyC Diane Mould, PhD, and Richard Upton, PhD, provide a brief overview of aspects of modeling and simulation as applied to many areas in drug development. ASCPT would like to thank the editorial leadership of CPT:PSP for their hard work and dedication toward the launch of this new journal. This outstanding team of experts includes: Piet van der Graaf, PhD, PharmD, Editor-in-Chief, Pfizer; Lena Friberg, PhD, Deputy-Editor-in-Chief, Uppsala University; Steve Duffull, PhD, University of Otago; Marc Gastonguay, PhD, Metrum Research Group; Douglas Lauffenburger, PhD, Massachusetts Institute of Technology; Don Mager, PharmD, PhD, University at Buffalo, SUNY; France Mentré, MD, PhD, Université Paris Diderot; Amin Rostami-Hodjegan, PharmD, PhD, University of Manchester; and, Paolo Vicini, PhD, Pfizer Global Research and Development. CPT:PSP, which is owned by ASCPT, and is an official journal of the International Society of Pharmacometrics (ISoP), is an online-only, Open Access journal published by Nature Publishing Group (NPG). The Journal will provide a unique international forum for scientists in the pharmacometrics and systems pharmacology space. The fully open access format of the journal, supported by an Article Processing Charge, means that all articles will be freely available for all to read immediately upon publication. In addition, articles publish under the Creative Commons License, enabling readers to download the article and share it with others. This platform will allow for and encourage open discourse on published works. Together, the CPT:PSP editorial leadership, ASCPT, ISoP, and NPG look to further define and shape the fields of pharmacometrics and systems pharmacology as applied to drug development. Look for new CPT:PSP papers to publish online each Wednesday at www.nature.com/psp. Keep abreast of the latest research by signing up to receive the electronic table of contents for CPT:PSP online at www.nature.com/psp. CPT:PSP welcomes submission of original research articles in the following areas: pharmacometrics, systems pharmacology modeling, disease modeling, model-based meta-analyses of clinical trials, pharmacokinetic-pharmacodynamic modeling, computational pharmacology, comparative efficacy. Visit http://www.nature.com/psp www.nature.com/psp for additional information on CPT:PSP, including the journal’s Aims and full Scope. Questions about manuscript submission, or to sign up to be a reviewer for CPT:PSP, can be directed to <mailto:[email protected]> [email protected].