time-to-event simulation based diagnostic

Dear NONMEM users I am currently performing a time-to-event analysis on binary data using a weibull distribution (time-varying hazard function). Using simulation based diagnositcs, I compared `simulated kaplan-Meier` to `observed kaplan-Meier`. However, fit looks to good to be true and I was actually suspecting a mispecification during the simulation process with PsN Here is the code used for vpc: vpc run2.mod -tte=RTTE -flip_comments -samples=100 I used (ICALL.EQ.4) and the flip-comment option in the model file. However, I am not sure if I have to generate a new simulation data set (each individual having a row for each possible observation time) or use the original one ? Any advises or comments are welcome Regards, -- François Gaudreault, Ph.D. Candidate Pharmacométrie / Pharmacometrics Chargé de cours / Lecturer Faculté de pharmacie / Faculty of Pharmacy Université de Montréal