RE: Time-varying PK DURING the course of study
Dear Khaled,
Time varying covariates are be included in a number of ways. This paper by
Ulrika Wählby et al. explores this subject in some depth.
Wählby, U., Thomson, A. H., Milligan, P. A., & Karlsson, M. O. (2004). Models
for time-varying covariates in population pharmacokinetic-pharmacodynamic
analysis. British journal of clinical pharmacology, 58(4), 367-377. Retrieved
from http://www.ncbi.nlm.nih.gov/pubmed/15373929
Kind regards
Dinko Rekic
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Khaled Nm
Sent: den 30 augusti 2012 14:45
To: [email protected]
Subject: [NMusers] Time-varying PK DURING the course of study
Dear nmusers,
I found it is difficult to account for age varying in PK parameter during the
course of the study.
Is there any way on how to define icreasing age as a covariate in the NONMEM
data file? A short example would be very useful for me.
thanks for your help.
khaled