Re: Covariate modeling course in Philadelphia Oct 22-23, 2012

On Mon, Aug 13, 2012 at 10:04 PM, Mats Karlsson <[email protected] > wrote: > Dear all,**** > > ** ** > > The Uppsala Pharmacometrics Group have over the years given a number of > intermediate and advanced courses on various topics related to population > PKPD modeling using NONMEM. **** > > Now we offer a new course: covariate model building. **** > > The course will provide participants with knowledge to efficiently tailor > methods to build and evaluate covariate models to different situations. The > participants will learn about pros and cons about commonly used methods, > but also learn about new methods* that can substantially improve the > efficiency of covariate modeling and increase the ability to diagnose the > quality of the resulting model. The course will be taught using NONMEM and > our freeware PsN (psn.sf.net) and Xpose (xpose.sf.net) that allow the use > of many different automated model building and evaluation methods. **** > > ** ** > > For more information please visit > http://www.med.upenn.edu/kmas/Mats/Matsindex.htm. **** > > ** ** > > ** ** > > *Some recent advances in covariate modeling methodology by the Uppsala > Pharmacometric Research Group**** > > ** ** > > *Authors* > > *Title* > > *Reference* > > Åsa Johansson and Mats O Karlsson**** > > Multiple imputation of missing covariates in NONMEM and evaluation of its > sensitivity to η-shrinkage**** > > WCoP 2012**** > > Vijay Ivaturi, Ron Keizer and Mats O. Karlsson**** > > A full random effects model for characterising covariate relations**** > > WCoP 2012**** > > Andrew C. Hooker and Mats O. Karlsson**** > > The Kaplan-Meier Mean Covariate plot (KMMC): a new diagnostic for > covariates in time-to-event models.**** > > PAGE 2012**** > > Takayuki Katsube, Akash Khandelwal, Andrew C Hooker, E. Niclas Jonsson, > Mats O Karlsson**** > > Characterization of Stepwise Covariate Model Building Combined with > Cross-Validation**** > > PAGE 2012**** > > Mats O Karlsson**** > > A full model approach based on the covariance matrix of parameters and > covariates**** > > PAGE 2012**** > > Khandelwal A, Harling K, Jonsson EN, Hooker AC, Karlsson MO.**** > > A fast method for testing covariates in population PK/PD Models.**** > > AAPS J. 2011 ;13:464-72. **** > > Bergstrand M, Hooker AC, Wallin JE, Karlsson MO.**** > > Prediction-corrected visual predictive checks for diagnosing nonlinear > mixed-effects models.**** > > AAPS J. 2011 ;13:143-51. **** > > Paul G. Baverel, Radojka M. Savic, Scott F. Marshall, Mats O. Karlsson**** > > A novel covariate search method intended for PKPD models with > nonparametric parameter distributions**** > > PAGE 2011**** > > Takayuki Katsube, Akash Khandelwal, Kajsa Harling, Andrew C Hooker, Mats O > Karlsson **** > > Evaluation of Stepwise Covariate Model Building Combined with > Cross-Validation**** > > PAGE 2011**** > > Ron J Keizer, Akash Khandelwal, Andrew C Hooker, Mats O Karlsson**** > > The bootstrap of Stepwise Covariate Modeling using linear approximations** > ** > > PAGE 2011**** > > Akash Khandelwal, Andrew C Hooker, and Mats O Karlsson**** > > Influence of Correlated Covariates on Predictive Performance for Different > Models**** > > PAGE 2011**** > > Vijay D Ivaturi, Andrew C Hooker, Mats O Karlsson**** > > Selection Bias in Pre-Specified Covariate Models**** > > PAGE 2011**** > > Åsa M. Johansson, Mats O. Karlsson**** > > Comparison of methods for handling missing covariate data**** > > PAGE 2011**** > > Akash Khandelwal, Kajsa Harling, E Niclas Jonsson, Andrew C Hooker, Mats O > Karlsson**** > > Covariate Model Building Using Linear Approximations**** > > PAGE 2010**** > > Savic RM, Karlsson MO.**** > > Importance of shrinkage in empirical bayes estimates for diagnostics: > problems and solutions.**** > > AAPS J. 2009 ;11:558-69. **** > > ** ** > > ** ** > > ** ** > > ** ** > > Best regards,**** > > Mats**** > > ** ** > > Mats Karlsson, PhD**** > > Professor of Pharmacometrics**** > > ** ** > > Dept of Pharmaceutical Biosciences**** > > Faculty of Pharmacy**** > > Uppsala University**** > > Box 591**** > > 75124 Uppsala**** > > ** ** > > http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/**** > > ** ** > > Phone: +46 18 4714105**** > > Fax + 46 18 4714003**** > > ** ** > -- Stefanie Hennig Division of Pharmacokinetics and Drug Therapy Department of Pharmaceutical Biosciences Uppsala University Biomedicum, Box 591 Uppsala, 75124 Sweden 41 Norman St Coorparoo, QLD 4151 Tel (home): +61-7-3397 7895 email: [email protected]