Re: Intel vs AMD
Thanks for all your comments and now I understand that there could be always slight differences between different CPU/architecture.
However, Would it possible that there could be differences in successful minimizations in nonmem runs. For example, for a same model, in one CPU/architecture the model run is minimized successfully with covariance step and in the other the run is terminated with rounding error.
I would like to say that I have not faced this problem yet. Just a question, to learn from your experience.
regards,
Martin
Quoted reply history
On 08/13/2012 03:13 PM, Bob Leary wrote:
> Even when using a non-Intel compiler (e.g. gnu compilers) with exactly the
> same compiler options and optimization levels on AMD and Intel that generates
> exactly the same
> code for both , there can be numerical differences between AMD and Intel
> processors.
>
> We did a study [1] on Phoenix NLME results using the gnu g77 compiler with
> different Intel processors and Windows operating systems going back to 2002
> and up to current generation processors (i3/i5/i7) and Windows 7. We generally
> got bit for bit identical results across every system tested when the compiler
> settings were the same. But AMD processors gave slightly different results.
> I found an AMD technical manual that indicated the probable reason - it advised
> that the AMD 80-bit x87 math floating point unit can give slightly different
> results than the corresponding Intel FPU.
> Indeed, we have found this to be the case in practice.
>
> {1} R. Leary et al, "Exact Reproducibility of Population PK/PD MLME Numerical
> Results across Different Computational Environments", PAGE 2011 (abstract 2042].
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Nick Holford
> Sent: Sunday, August 12, 2012 4:56 PM
> To: nmusers
> Subject: Re: [NMusers] Intel vs AMD
>
> Mark,
>
> I think you may not be fully appreciating the terms of the agreement when you say
> "it is generally accepted that Intel continues to impair the optimization on AMD
> CPU".Under the terms of the agreement (which you provide below) it is perfectly OK
> for Intel to optimize their compilers for Intel CPUs without including any optimization
> for AMD CPUs.
> Furthermore they are not required to provide any optimization for AMD CPus.
> Therefore, unless Intel don't know how to optimize compilers you must expect
> the Intel compiler to perform better on an Intel CPU.
>
> This issue might (or might not) be relevant to Martin's query about
> 'differences'. He does not specify the kind of difference e.g. faster?
> more accurate?. It may be possible to choose compiler options that produce
> identical numerical results on both CPUs but at the price of speed.
>
> Rik Schoemaker suggested using these Intel compiler options /nologo /nbs /w /Gs
> /fp:strict to obtain consistent numerical results
> ( http://www.cognigencorp.com/nonmem/current/2011-May/3266.html) with different
> NONMEM 7 versions across different operating systems. Perhaps these options
> would ensure numerical consistency across different CPU types.
>
> Best wishes,
>
> Nick
>
> On 13/08/2012 8:27 a.m., Mark Sale - Next Level Solutions wrote:
>
> > Martin
> > Yes, the results can be different. Intel has been accused of
> > "crippling" the executable when the Intel compiler is used on AMD CPUs
> > http://www.agner.org/optimize/blog/read.php?i=49
> >
> > by turning off all optimization - they actually pretty much admitted
> > this in the lawsuit - but explained that it was for the benefit of the
> > customer - sort of like in the 1980's when Microsoft pretty much
> > disabled WordPerfect with every new OS release.
> >
> > and yes, different optimization setting will give different results,
> > 32 bit will also give different results from 64 bit. Sometimes the
> > phase of the moon, or the users astrological sign makes a different as
> > well ;-) Below is from the settlement:
> > Intel shall not include any Artificial Performance Impairment in any
> > Intel product or require any Third Party to include an Artificial
> > Performance Impairment in the Third Party’s product. As used in this
> > Section 2.3, “_Artificial Performance Impairment_” means an
> > affirmative engineering or design action by Intel (but not a failure
> > to act) that (i) degrades the performance or operation of a Specified
> > AMD product, (ii) is not a consequence of an Intel Product Benefit and
> > (iii) is made intentionally to degrade the performance or operation of
> > a Specified AMD Product. For purposes of this Section 2.3, “_Product
> > Benefit_” shall mean any benefit, advantage, or improvement in terms
> > of performance, operation, price, cost, manufacturability,
> > reliability, compatibility, or ability to operate or enhance the
> > operation of another product.
> >
> > In no circumstances shall this Section 2.3 impose or be construed to
> > impose any obligation on Intel to (i) take any act that would provide
> > a Product Benefit to any AMD or other non-Intel product, either when
> > such AMD or non-Intel product is used alone or in combination with any
> > other product, (ii) optimize any products for Specified AMD Products,
> > or (iii) provide any technical information, documents, or know how to AMD.
> >
> > But, it is generally accepted that Intel continues to impair the
> > optimization on AMD CPU.
> > So, to answer your question, I don't think there is any way to insure
> > consistent results between Intel and AMD CPUs.
> >
> > Mark
> >
> > Mark Sale MD
> > President, Next Level Solutions, LLC
> > http://www.NextLevelSolns.com
> > 919-846-9185
> > A carbon-neutral company
> > See our real time solar energy production at:
> > http://enlighten.enphaseenergy.com/public/systems/aSDz2458
>
> --
> Nick Holford, Professor Clinical Pharmacology
>
> First World Conference on Pharmacometrics, 5-7 September 2012 Seoul, Korea
> http://www.go-wcop.org
>
> Dept Pharmacology& Clinical Pharmacology, Bldg 505 Room 202D University of
> Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
> tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
> email: [email protected]
> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
>
> _________________________________________________________________
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