RE: Time after dose

From: [email protected] [mailto:[email protected]] On Behalf Of siwei Dai Sent: Thursday, July 05, 2012 12:17 PM To: [email protected] Subject: [NMusers] Time after dose Hi, Everyone: I am having trouble with getting the correct output of TAD (time after dose) and hoping to get your suggestions. Here is a brief description of my dataset: drug was given multiple dosing every 12 hours. All the dosing events were recorded in the input file. Observations were taken right before the last dose (predose), and 0.5, 1, 2, 4, 8 hrs post-dose. I have used this code to calculate the TAD IF(AMT.GT.0) THEN TDOS=TIME TAD=0.0 ENDIF IF (AMT.EQ.0) TAD=TIME-TDOS In the output, the TADs calculated for the predose observation, instead of being a negative value, are closed to 12 and larger than the one for 8 hrs observations. It is obviously wrong and it give me wrong individual plots. I tried to find useful information in NM archive but cannot find any that suitable for my situation. Any suggestions are greatly appreciated! Thank you in advance for your help! Siwei This electronic transmission may contain confidential and/or proprietary information and is intended to be for the use of the individual or entity named above. If you are not the intended recipient, be aware that any disclosure, copying, distribution or use of the contents of this electronic transmission is prohibited. If you have received this electronic transmission in error, please destroy it and immediately notify us of the error. Thank you.