Re: Question about interoccation variability
Hi Klaas and Jean,
Thanks a lot for your immediate response and input. I will definitely test
that whether having IOV on F1 will help.
But I have a more general question about IOV. Can you comment on having one
IOV in the model versus having five different IOVs across five different
occasions? Is it reasonable to have different IOVs in the model?
Thanks a lot for your generous help.
Best,
Claire
Quoted reply history
On Tue, Jul 10, 2012 at 6:42 PM, Klaas Prins <[email protected]>wrote:
> I think I would try IOV on F1 first before putting it on KA like Jean
> suggested but above all I think there is an essential element missing in
> your code. IOV is variability between occasions on top of inter individual
> variability.
>
> So do something like:
> F1=1
> F1=THETA(1)*EXP(ETA(6)+BOVKA)
> $OMEGA 0.25 ; IIV F1
>
> Furthermore, there may be other elements contributing to the inability to
> predict Cmax well, such as more complex absorption features. I think we
> lack info to comment on that.
>
> HTH, Klaas
>
>
> On 10 jul. 2012, at 23:56, "Lavigne, Jean" <[email protected]>
> wrote:
>
> > KA=THETA(1)*EXP(BOVKA)
>
>
--
Xu, Claire
Ph.D Candidate
Division of Clinical Pharmacology, Wishard Hospital
Indiana University School of Medicine
1001 West 10th Street, Myers W7122
Indianapolis, IN 46202
T - 317/7558242