Files for multiple dose superimpositon into transit compartment
A paper was recently published for which I contributed some NM-TRAN
input files, implementing two approaches for modeling multiple doses
into a transit compartment. They include an example of a user-written
function (FUNCA) that may be of interest.
Bob Bauer has put these files into an ftp site:
ftp://nonmem.iconplc.com/Public/nonmem/transit_compartment/
The paper is:
Implementation of dose superimposition to introduce multiple doses
for a mathematical absorption model (transit compartment model)
Jun Shen, Alison Boeckmann & Andrew Vick
Journal of Pharmacokinetics and Pharmacodynamics
ISSN 1567-567X Volume 39 Number 3
J Pharmacokinet Pharmacodyn (2012) 39:251-262 DOI
10.1007/s10928-012-9247-3
The original paper that modeled single doses into a transit compartment
is:
J Pharmacokinet Pharmacodyn (2007) 34:711–726 DOI
10.1007/s10928-007-9066-0
Implementation of a transit compartment model for describing drug
absorption in pharmacokinetic studies
Radojka M. Savic · Daniël M. Jonker · Thomas Kerbusch · Mats O. Karlsson
--
Alison Boeckmann
[email protected]