omega matrix - friendly suggestion

From: NONMEM Date: June 12, 2012 technical Source: mail-archive.com
Hello NONMEM Community, Sometimes it takes more time to choose the best omega matrix than to develop a PD model. Selecting the omega matric is a tedious, time consuming and less creative part of the model development. I hope you feel my pain. Will it be helpful to rewrite the NONMEM software so that any element of the omega matrix can be fixed to any value? It may look like this: $OMEGA BLOCK (4) 3.60E-02 FIX 0.01 3.23E-02 0.03 0 FIX 1.66E-02 0.01 0 FIX 0.03 FIX 1.66E-02 This change can make many NONMEM users happy. Thanks! Pavel
Jun 12, 2012 NONMEM omega matrix - friendly suggestion
Jun 12, 2012 Kenneth Kowalski RE: omega matrix - friendly suggestion
Jun 13, 2012 Paolo Denti Re: omega matrix - friendly suggestion
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Jun 15, 2012 Bob Leary RE: omega matrix - friendly suggestion