BAPKPD Luncheon Seminar

Bay Area Pharmacokinetic and Pharmacodynamics (BAPKPD) Network Invites You to a Luncheon Seminar. 'A Mechanistic Model of the Renin-Angiotensin System (RAS) in the Renal Circulation' by Dr. Arthur Lo. Time: May 3 (Thursday), 2012, 11:30 AM-1:30 PM PDT. Location: Theravance, 901 Gateway Blvd, South San Francisco, CA 94080, Room 1004/5. Register at http://bapkpd.org/upevent.html http://bapkpd.org/upevent.html . Abstract: With the increased number of therapies for hypertension focusing on the renin-angiotensin system (RAS), there is evidence that some therapies are more effective at preventing end organ damage. Although the role of angiotensin II (Ang II) is well known and the systemic concentrations well characterized, the dynamics of Ang II within the kidney itself are less well characterized. This talk will walk through the development of a mechanistic model of the RAS that was built to predict the effects of different types of therapies on the concentrations of Ang II. The focus will be on teasing out RAS dynamics in the renal circulation, a location that is difficult to directly assay local peptide concentrations. Alternative sources of data for calibration and validation will be discussed, as well as the research applications of the model. Toufigh Gordi, PhD