Next Rosa Impact Webinar

Using mathematical models to set design criteria for antibody-based therapies by Dr. Birgit Schoeberl Vice President of Discovery Merrimack Pharmaceuticals April 17, 2012 1:00 - 2:00 pm EDT Monoclonal antibodies are valuable as anticancer therapeutics because of their ability to selectively bind tumor-associated target proteins like receptor tyrosine kinases. However, most tumors are addicted to more than one pathway which asks for rational antibody combinations or bispecific antibodies. In our presentation, we will illustrate the use of kinetic computational models that capture protein­protein interactions to explore antibody combinations vs. bispecific antibodies, different formats of bispecific antibodies, to set antibody design specifications such as affinity and valence, and to predict potency. The purpose of the ³Impact² series is to foster the use of M&S activities in all phases of drug development by illustrating the advantages and enhancing the applicability of M&S in product discovery, development, and marketing programs. The series is intended for drug development project team members from discovery to phase 4 clinical trials. This includes pharmacologists, ADME scientists, PK/PD modelers, clinical pharmacologists, clinical development team members, regulatory affairs specialists, and other interested professionals. Register for this free webinar at www.rosaandco.com/webinar http://www.rosaandco.com/webinar . After registering you will receive a confirmation email containing information about joining the webinar. More information about the webinar series, an archive of past webinars, and a list of future webinar speakers may be found at www.rosaandco.com/webinar http://www.rosaandco.com/webinar . Please allow 5-10 minutes for a Java applet to be installed on your computer prior to joining our webinar series for the first time. Toufigh Gordi, PhD President, PK/PD and Clinical Pharmacology Services Rosa & Co. LLC: www.rosaandco.com http://www.tgordi.com/ E-mail: [email protected] <mailto:[email protected]> Tel.: 408-480-7314 Fax: 408-370-9810