Re: PK/PD modeling - fixing population paramterers vs. fixing both pop. and individual parameters
Dear Pavel,
Yes there is, one was published online just recently:
Lacroix BD, Friberg LE, Karlsson MO.
Evaluation of IPPSE, an alternative method for sequential population PKPD
analysis.
J Pharmacokinet Pharmacodyn. 2012 Jan 21.
In addition to presenting the 2 methods you're referring to, fixing
population PK parameters or conditioning on individual PK parameters, it
includes a comparison with the simultaneous PKPD fit and introduces an
approach accounting for uncertainty in the PK parameters.
Best regards,
Elodie
--
Elodie L Plan, Pharm.D, Ph.D
Metrum Research Group, LLC
2 Tunxis Road, Suite 112
Tariffville, CT 06081
*(860) 560-3770*
*(860) 735-7043*
Quoted reply history
On 1 February 2012 11:15, <[email protected]> wrote:
> Hello NONMEM Team,
>
> We usually try to separate PK and PD models and the reasons are
> obvious. There are different ways to separate the models. Are there any
> good references which show advantages and disadvantages of fixing
> population paramterers in the PD model ann allowing the model to estimate
> individual PK parameters vs. fixing both population and individual PK
> parameters?
>
> Thanks!
>
> Pavel
>