Two Postdoctoral reasearch positions at UCB New Medicines - Research Centre

Dear all, UCB ( http://www.ucb.com/) is a global leader in the biopharmaceutical industry dedicated to the research, development and commercialization of innovative pharmaceutical and biotechnology products in the fields of central nervous system disorders, and immune and inflammatory disorders. UCB focuses on securing a leading position in severe disease categories. At the Research Centre of "UCB New Medicines", we are looking to recruit two talented PhD scientists to join our post-doc programme: 1) Quantitative and Systems Pharmacology Modeling Post-Doc - extending our mechanistic and quantitative understanding of disease and causality. Systems Pharmacology involves the application of systems biology approaches, combining large scale experimental studies with model-based computational analyses, to study drug activities, targets and effects. The objective of the 2 year post-doctoral position will be to work within a drug discovery and early clinical development environment to develop a mechanistic model which captures and describes the dynamic relationship between key immunological events and inflammatory mediators of interest in rheumatoid arthritis (RA). The systems model developed will then be used to generate hypotheses on the interplay and significance of these mediators in disease, as well as the ability to identify and rank biomarkers of disease progression/severity and potential drug candidate response. The opportunity will require the post-doc to work closely with other systems pharmacology scientists/engineers, therapeutic area experts and cell biologists. The opportunity will be expected to generate at least 3 high impact peer reviewed publications. Preferred Background: PhD in mechanistic PK-PD, Engineering or Applied Mathematics Location: Either UK (Slough) or Belgium Please contact: [email protected] or [email protected] 2) Pharmacometric Methodology Post-Doc: Advancement of model-based drug development. Model based drug development (MBDD) is advocated by industry, academia and regulatory agencies as a powerful tool to improve the efficiency of drug development. Clinical Pharmacometricians,Statisticians and Pharmacologists play a lead role in implementing MBDD because of their ability to integrate mechanistic, pre-clinical and clinical information, using quantitative approaches to address complex questions arising during drug development. For example, one aspect of model based drug development is the application of advanced PK-PD models to the exploration of innovative and early decision making clinical trials. The objective of the 2 year post-doctoral position will be to work within an early clinical development environment in an applied setting to explore the application and nuances of various trial designs, choice and sensitivity of endpoints, predicting the probability of success of trials based on interim evaluation and the impact of incorporating active comparators. Such problems unite clinicians and the advanced modeller/statistician, but indeed require advance statistical modeling theory, thinking and simulation to propose solutions. The opportunity will require the post-doc to work closely with other modellers/statisticians as well as clinicians, and is expected to generate at least 3 high impact peer reviewed publications, and a contribution to applied statistical methodology. Preferred Background: PhD in Applied Statistics, Mathematics or Pharmacometrics. Location: Either UK (Slough) or Belgium Please contact: [email protected] or [email protected] Best regards, Rocio Rocio Lledo-Garcia, PhD Modeling & Simulation specialist UCB Celltech 208 Bath Road, Slough, UK -------------------------------------------------------- UCB Celltech is the UK branch of UCB Pharma S.A., a company registered in Belgium with registered offices at Allee de la Recherche 60, 1070 Brussels, Belgium, KBO/BCE nr. 0403.096.168, RPR/RPM Brussels. UCB Celltech's UK branch registration number is BR009137 and its UK representative office is at 208 Bath Road, Slough, Berkshire SL1 3WE. -------------------------------------------------------- Legal Notice: This electronic mail and its attachments are intended solely for the person(s) to whom they are addressed and contain information which is confidential or otherwise protected from disclosure, except for the purpose for which they are intended. Dissemination, distribution, or reproduction by anyone other than the intended recipients is prohibited and may be illegal. If you are not an intended recipient, please immediately inform the sender and return the electronic mail and its attachments and destroy any copies which may be in your possession. UCB screens electronic mails for viruses but does not warrant that this electronic mail is free of any viruses. UCB accepts no liability for any damage caused by any virus transmitted by this electronic mail. (Ref: #*CUK0308)