Re: How to incorporate sampling sites as a covariate?
Title: Paul R
Dear Huali:
It depends. What are you trying to do with the two data sets?
One of the classic articles on this subject is by Dr Chiou:
The
phenomenon and rationale of marked dependence of drug
concentration on blood sampling site. Implications in
pharmacokinetics, pharmacodynamics, toxicology and therapeutics
(Part I).
Chiou WL.
Clin
Pharmacokinet . 1989 Sep;17(3):175-99.
Paul
On 1/5/2012 1:34 PM, Wu, Huali wrote:
Dear NMusers:
I have a question regarding covariates in pop PK analysis.
Has anyone used sampling sites from subjects as a covariate
for PK parameters? In my dataset, each subject had samples
from carotid arterial and jugular vein. And the PK profiles
from different sites appeared differently. I was wondering if
it is possible to incorporate sampling sites as a covariate.
Thank you very much for any suggestions!
Best regards,
Huali
--
Paul R.
Hutson, Pharm.D.
Associate
Professor
UW School
of Pharmacy
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