Reminder: Dr. Maurer's webinar next week

This is a reminder that Dr. Maurer's webinar Translational Modeling & Simulation in Support of Rational Drug Discovery: Principles, Challenges, and Examples will take place on December 13, 2011 at 1:00 pm EST (GMT -5:00). One of the most serious threats to sustained pharmaceutical innovation is the rapidly rising cost of research and development experienced over the past several decades. This exponential rise in cost has been attributed to a variety of factors including increasing technology investments, rising regulatory and commercial hurdles, and higher attrition rates. Among these factors, attrition due to insufficient efficacy and / or safety stands out as a major contributor. Historically high rates of efficacy and safety related attrition suggest that that there is often insufficient knowledge upon which critical decisions in drug discovery are made, namely: which biochemical targets to pursue and which chemical matter to bring forward into the clinic. Preclinical modeling and simulation (e.g. systems biology, PK/PD) is a useful approach to integrating biological information toward the selection of the most promising targets and the design of the most promising chemical matter. As such, over the past several years, quantitative modeling and simulation has become increasingly popular among pharmaceutical companies seeking to reduce attrition. This presentation will provide the rationale for quantitative modeling and simulation, guiding principles for successful implementation of fit for purpose models, and examples illustrative of value added in drug discovery. Dr. Maurer's presentation is a part of the monthly world-wide webinar series “Impact of Modeling & Simulation in Drug Development” hosted by Rosa & Co. LLC. The purpose of the “Impact” series is to foster the use of M&S activities in all phases of drug development by illustrating the advantages and enhancing the applicability of M&S in product discovery, development, and marketing programs. The series is intended for drug development project team members from discovery to phase 4 clinical trials. This includes pharmacologists, ADME scientists, PK/PD modelers, clinical pharmacologists, clinical development team members, regulatory affairs specialists, and other interested professionals. Register for this free webinar at www.rosaandco.com/webinar. After registering you will receive a confirmation email containing information about joining the webinar. More information about the webinar series, an archive of past webinars, and a list of future webinar speakers may be found at www.rosaandco.com/webinar. Please allow 5-10 minutes for a Java applet to be installed on your computer prior to joining our webinar series for the first time. Toufigh Gordi, PhD President, PK/PD and Clinical Pharmacology Services Rosa & Co. LLC: www.rosaandco.com E-mail: [email protected] Tel.: 408-480-7314 Fax: 408-370-9810 The information contained in this e-mail message, e-mail message sequence, and/or any enclosures is confidential, and it may be privileged and protected from unauthorized use and/or disclosure. If you are not the intended recipient, any use, dissemination, distribution, or copying is strictly prohibited. If you received this e-mail in error, PLEASE NOTIFY THE SENDER immediately and destroy this message, any enclosures, and any copies of the message and/or the enclosures. Thank you.