RE: Truncated Emax

________________________________ From: owner-nmusers Behalf Of Francois Gaudreault Sent: Monday, December 19, 2011 21:40 To: nmusers Subject: [NMusers] Truncated Emax Dear NM users I am currently developing a PK PD model for local anesthetics using a sequential approach with ADVAN6. The PD model is a sigmoid Emax with an effect compartment (Ce). The intensity and duration of nerve blockade are monitored throughout the perioperative period in patients using a quantitative pharmacodynamic endpoint, i.e, the current perception threshold (CPT) REF: Can. J. Anesth, 57 (S1) 2010). Briefly, CPT is evaluated before and after the administration of the local anesthectic. Data are normalized by baseline using the following equation : (observed-baseline) / (max-baseline) *100 (%) Here is the problem. The device only goes to a maximum of 10 mA. In some patients, the real Emax is much higher. Any ideas on how handle a truncated Emax ? Thanks in advance -- Franois Gaudreault, Ph.D. Candidate Pharmacomtrie / Pharmacometrics Charger de cours / Lecturer Facult de pharmacie / Faculty of Pharmacy Universit de Montral Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.