time dependant function

Dear NMusers, I was trying to build a published model (Woo et al, Cancer Chemother. Pharmacol, 2008) in NONMEM and Berkeley Madonna, where the differential equations contain time dependant functions. In this particular function the amount in one compartment at a certain time point is addressed. E.g. S(t)=1+(SMAX*EPO(t))/(SC50+EPO(t)) and in the ODEs S(t), S(t-TP1), S(t-TP2) and so on is needed. As EPO(t) is driven by a feedback loop, I didn't succeed by just starting multiple compartments with a delay. Any ideas are welcome. Kind regards, Hauke cid:[email protected]_bonnKlinische Pharmazie Hauke Rühs Apotheker Pharmazeutisches Institut Klinische Pharmazie An der Immenburg 4 53121 Bonn Tel: 0228 73-5781 Fax: 0228 73-9757 http://www.klinische-pharmazie.info/ www.klinische-pharmazie.info <<attachment: image001.jpg>> <<attachment: image002.gif>>