RE: "ERROR IN LSODA: CODE -1"

From: Jeroen Elassaiss-Schaap Date: September 23, 2011 technical Source: cognigen.com
Nick, The help entry makes sense to me. When one assumes that both tolerances are converted as tolerance = 10^(-TOL) they are appropriately scaled. And with regard to the html fragment you referred to, it seems to me like a pragmatic advice rather than stating that those numbers should be kept equal. It also makes sense that if you want more accurate positive numbers you also may want the zero defined more accurately. Thanks for the solver link! Best regards, Jeroen
Quoted reply history
-----Original Message----- From: owner-nmusers Behalf Of Nick Holford Sent: Thursday, September 22, 2011 23:02 To: nmusers Subject: Re: [NMusers] "ERROR IN LSODA: CODE -1" Hi, I think it may be useful to understand that numerical differential equation solvers require an absolute tolerance as well as a relative tolerance. See http://www.gnu.org/software/octave/doc/interpreter/Differential_002dAlgebraic-Equations.html for an explanation and example of how these tolerances are typically used. The need for an absolute tolerance is when the correct solution of the DE is zero. In this case a relative tolerance cannot guide the numerical DE solver to achieve a sufficiently precise solution. An absolute tolerance is analogous to an additive residual error while relative tolerance is analogous to a proportional residual error. Thus the absolute and relative tolerance criteria have no direct numerical relationship to each other. The online NM7 help describes ATOL like this: ATOL=n Absolute tolerance. Used only with ADVAN13, for which TOL is a rela- tive tolerance. The default is 12; a smaller value (equal to TOL) may improve run time. May also be set with $COVARIANCE record. The NM7 definition is rather mysterious. If ATOL is really an absolute tolerance criterion then a value of 12 would be ridiculous if the scale of the solution was in say the 1 to 100 range. Perhaps we are expected to guess that ATOL means 10D-12? I cannot see any reason to suggest why ATOL should be set equal to TOL because these numbers are like apples and oranges and cannot be compared. Some ODE solvers allow ATOL as a vector to match the DADT vector so that the absolute tolerance for each solution could be individually specified. Nick Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.
Sep 22, 2011 NONMEM "ERROR IN LSODA: CODE -1"
Sep 22, 2011 Jeroen Elassaiss-Schaap RE: "ERROR IN LSODA: CODE -1"
Sep 22, 2011 Jeroen Elassaiss-Schaap RE: "ERROR IN LSODA: CODE -1"
Sep 22, 2011 Jan-Stefan van der Walt Re: RE: "ERROR IN LSODA: CODE -1"
Sep 22, 2011 Robert Bauer RE: "ERROR IN LSODA: CODE -1"
Sep 22, 2011 Nick Holford Re: "ERROR IN LSODA: CODE -1"
Sep 23, 2011 Jeroen Elassaiss-Schaap RE: "ERROR IN LSODA: CODE -1"
Sep 23, 2011 Jeroen Elassaiss-Schaap RE: "ERROR IN LSODA: CODE -1"
Sep 23, 2011 Nick Holford Re: "ERROR IN LSODA: CODE -1"