RE: How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7
Li Li,
In addition you may try ADVAN9, though ADVAN13 may have advantages over ADVAN9.
Matt.
Quoted reply history
-----Original Message-----
From: owner-nmusers
Behalf Of Luann Phillips
Sent: Wednesday, June 22, 2011 4:44 PM
To: Li Li
Cc: nmusers
Subject: Re: [NMusers] How to Increase Maximum NO. of Evaluations of Differential Equation in NONMEM 7
Li Li,
If this is the model that you have described previously, you may want to
try ADVAN8 or ADVAN13. With the cusps that the on/off nature of your
rate constant a stiff diff. eq. solver may perform better.
best regards,
Luann Phillips
Director PK/PD
Cognigen Corporation
Li Li wrote:
> Hi,
>
> I am using ADVAN 6 to do some PKPD modeling and got this error message:
> NUMERICAL DIFFICULTIES WITH INTEGRATION
> ROUTINE.
>
> MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 1000000,
> EXCEEDED.
>
> I know in NONMEM 6 you may use following code to increase maximum number
> of integration of differential equation:
> "FIRST
> " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5
> " IMAX0000000
> But in NONMEM 7 it gave error message:
> (WARNING 113) VERBATIM CODE CONTAINS "COMMON". IF THIS IS NOT A
> USER-DEFINED COMMON, IT SHOULD BE REPLACED BY THE APPROPRIATE MODULE.
> CREATING MUMODEL ROUTINE...
>
> Thus, how can I increase maximum number of integration of differential
> equation in NONMEM 7?
>
> Thank you.
>
> lili
This e-mail (including any attachments) is confidential and may be legally privileged. If you are not an intended recipient or an authorized representative of an intended recipient, you are prohibited from using, copying or distributing the information in this e-mail or its attachments. If you have received this e-mail in error, please notify the sender immediately by return e-mail and delete all copies of this message and any attachments.
Thank you.