Re: transit compartment question
Dear Ethan,
My few cents...
Transit compartment model is generally used to account for
delay in the effect (e.g Cell growth;
Friberg et al JPCT 2002), (delay in placebo effect ; Mould
et al CPT 2007) or (to account for delay in absorption; Savic et al, 2007).
It is numerically stable to define the transfer rate constants
(Ktr) as mean transit time (MTT) which are larger numbers than rate constant
and then let the rate constant be n/MTT.
MTT = THETA (1)*EXP(ETA(1))
N= number of transit compartments
KTR = N/MTT
Best Regards,
Venkatesh Pilla Reddy,
Phd Student,
University of Groningen
--- On Tue, 8/3/11, Ethan Wu <[email protected]> wrote:
Quoted reply history
From: Ethan Wu <[email protected]>
Subject: [NMusers] transit compartment question
To: "[email protected]" <[email protected]>
Date: Tuesday, 8 March, 2011, 11:41 PM
Hi all,
I was implementing transit compartment for a absorption model for the first
time. I could not understand why the relationship between mean transit time and
transit rate is MTT=(n+1)/Ktr.
Could someone help me understand?
Thank you.