NONMEM 7: Problems with example10.ctl and example10l.ctl

Dear all, we are testing our installation of NONMEM 7.1.2. However we have problems when we execute the provided examples 10 and 10l from the examples directory. Both examples terminate for the last estimation method (Laplacian Conditional Estimation with Interaction) with a POSTERIOR DENSITY IS NON-POSITIVE-DEFINITE message during the initial iterations. Looking at the reference example results we find that in example10.res and example10l.res there are gradients that are 0 from the beginning and some messages from NMTRAN (warnings 31 + 41) which indicate the presence of unused parameters in the model (??) Looking at the provided ctl files we found that the prior information for OMEGA is missing the FIX attribute. However when we correct the ctl files accordingly, example 10 still terminates with the above message, while example 10l now runs fine (even able to complete the covariance step). As anyone else also come across this issue? How serious would you evaluate the fact that our installation of NONMEM behaves differently with regard to installation qualification? Thank you in advance and best regards Matthias Frede _________________________________________ Bayer Schering Pharma Aktiengesellschaft BSP-GDD-CP-TS-M&S-M&S CV/H Phone: +49 202 36 4830 Fax: +49 202 36 3998 E-mail: [email protected] Web: http://www.bayerscheringpharma.de Vorstand: Andreas Fibig, Vorsitzender | Andreas Busch, Ulrich Köstlin, Kemal Malik, Bernd Metzner Vorsitzender des Aufsichtsrats: Richard Pott Sitz der Gesellschaft: Berlin | Eintragung: Amtsgericht Charlottenburg HRB 283 B