RE: Inclusion of Analytical Expressions in NONMEM control file
Dear all
Many thanks for your feedback and apologies for my late reply.
Maybe my first message wasn't clear enough but I'm interested in "bypassing" the existing libraries in PREDPP in order to include the model's analytical solution instead of an ADVAN or set of differential equations ($DES).
I think I got the solution through Leonid's & Nick's replies. Thank you all for your valuable feedback.
Best
Georgios
Quoted reply history
From: owner-nmusers
Behalf Of Nick Holford
Sent: 03 February 2011 18:39
To: nmusers
Subject: Re: [NMusers] Inclusion of Analytical Expressions in NONMEM control file
Georgios,
Leonid has already asked you to make it clearer what you are trying to do.
Coding "analytical expressions" that do not involve $DES or other PREDPP subroutines in NONMEM may be done using $PRED e.g.
$INPUT ID DOSE DV
$THETA 1
$OMEGA 1
$SIGMA 1
$PRED
D50=THETA(1)*EXP(ETA(1)
Y=DOSE/(DOSE+D50) + EPS(1)
This estimates the D50 for a dose-response relationship with an exponential random effects model for D50 and an additive random effect for the residual error. The dose response is assumed to have a maximum of 1 in this very simple example.
Nick
On 4/02/2011 6:49 a.m., Leonid Gibiansky wrote:
Addition:
I assumed that you need to use analytical equations; if you need just expressions, you can do it in the error block like
TEMP=A(1)/V1
Y=(TEMP**2+1)**0.5 + EPS(1)
If you need something else, please, give an example of what exactly you are trying to implement
Regards,
Leonid
On 2/3/2011 12:39 PM, Leonid Gibiansky wrote:
you can use ADNVAN9 $AES (see manual) although it is much better
(quicker and more stable) to solve them (if possible) analytically.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: http://www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 2/3/2011 11:50 AM, Georgios Vlasakakis wrote:
Dear NONMEM users
Has anyone ever tried to include analytical expressions within a control
file in NOMEM? I guess that would obviously imply the use of a routine
alternative to the $DES.
I'd appreciate if you could provide me with some tips or a short example
on that.
Many thanks in advance,
Georgios
/Georgios Vlasakakis, BEng///
Post-Doctoral Fellow
GlaxoSmithKline, Middlesex, UB11 1BT, Stockley Park
CPMS Development and Technologies
https://connect.gsk.com/sites/cpms/TandD/Pages/default.aspx https://connect.gsk.com/sites/cpms/TandD/Pages/default.aspx
Quantitative Sciences, R&D
Internal Phone Number: 792 2047
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email: georgios.x.vlasakakis
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: n.holford
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