Re: Inclusion of Analytical Expressions in NONMEM control file
Georgios,
Leonid has already asked you to make it clearer what you are trying to do.
Coding "analytical expressions" that do not involve $DES or other PREDPP subroutines in NONMEM may be done using $PRED e.g.
$INPUT ID DOSE DV
$THETA 1
$OMEGA 1
$SIGMA 1
$PRED
D50=THETA(1)*EXP(ETA(1)
Y=DOSE/(DOSE+D50) + EPS(1)
This estimates the D50 for a dose-response relationship with an exponential random effects model for D50 and an additive random effect for the residual error. The dose response is assumed to have a maximum of 1 in this very simple example.
Nick
Quoted reply history
On 4/02/2011 6:49 a.m., Leonid Gibiansky wrote:
> Addition:
>
> I assumed that you need to use analytical equations; if you need just expressions, you can do it in the error block like
>
> TEMP=A(1)/V1
> Y=(TEMP**2+1)**0.5 + EPS(1)
>
> If you need something else, please, give an example of what exactly you are trying to implement
>
> Regards,
> Leonid
>
> On 2/3/2011 12:39 PM, Leonid Gibiansky wrote:
>
> > you can use ADNVAN9 $AES (see manual) although it is much better
> > (quicker and more stable) to solve them (if possible) analytically.
> > Leonid
> >
> > --------------------------------------
> > Leonid Gibiansky, Ph.D.
> > President, QuantPharm LLC
> > web: www.quantpharm.com
> > e-mail: LGibiansky at quantpharm.com
> > tel: (301) 767 5566
> >
> > On 2/3/2011 11:50 AM, Georgios Vlasakakis wrote:
> >
> > > Dear NONMEM users
> > >
> > > Has anyone ever tried to include analytical expressions within a control
> > >
> > > file in NOMEM? I guess that would obviously imply the use of a routine
> > > alternative to the $DES.
> > >
> > > I’d appreciate if you could provide me with some tips or a short example
> > >
> > > on that.
> > >
> > > Many thanks in advance,
> > >
> > > Georgios
> > >
> > > /Georgios Vlasakakis, BEng///
> > >
> > > Post-Doctoral Fellow
> > >
> > > GlaxoSmithKline, Middlesex, UB11 1BT, Stockley Park
> > >
> > > CPMS Development and Technologies
> > > https://connect.gsk.com/sites/cpms/TandD/Pages/default.aspx
> > >
> > > Quantitative Sciences, R&D
> > >
> > > Internal Phone Number: 792 2047
> > >
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> > >
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--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology& Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
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