double peak absoprtions
Dear all
I am trying to implement a double peak absorption profile for a compound
using NMVI, I am using the following program to model the fact the drug is
absorbed into unequal doses each absorbed by a first order process governed
by different rate constant and lag times . Do you agree with this model?
$PK
;disposition parameters
TVCL=THETA(1)
CL=TVCL*EXP(ETA(1))
TV=THETA(2)
V=TV*EXP(ETA(2))
TVQ=THETA(3)
Q=TVQ*EXP(ETA(3))
TV2=THETA(4)
V2=TV2*EXP(ETA(4))
KA1=THETA(5)
KA2=THETA(6)
ALAG1=THETA(7)
;lagtime for 2nd release
ALAG2=ALAG1+THETA(8)
;F1 fraction of the dose absorbed through the first process
F1=THETA(9)
;F2 fraction of the dose absorbed through the 2nd process
F2=1-F1
;SCALE FACTOR
S2=V/1000
K20=CL/V
K23=Q/V
K32=Q/V2
$DES
DADT(1) = -F1*ALAG1*KA1*A(1)-F2*ALAG2*KA2*A(1)
DADT(2) = F1*ALAG1*KA1*A(1)+F2*ALAG2*KA2*A(1)+K32*A(3)-K23*A(2)-K20*A(2)
DADT(3) = -K32*A(3)+K23*A(2)
Virginie GUALANO
PhInC DEVELOPMENT -