RE: Differences in Covariance analysis between FOCE vs. IMPMAP
Bob:
I have not found a test problem with an OMEGA BLOCK greater than 8. The
largest I found was for 8 but I am still looking.
However, this control stream will definitely not run but I do not think the
problem is with the size of the block. The zero off-diagonal elements in the
last row should terminate the run. Also, I believe the correlations for the
rest of the matrix are all 1 and this could also be problematic. The user may
not have looked through the rest of the file.
I think the entire output (.res) file as well as the cs and data file if
possible should be requested.
Tom
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]] On
Behalf Of Dieter Menne
Sent: Monday, September 13, 2010 4:41 AM
To: [email protected]
Cc: Bauer, Robert
Subject: RE: [NMusers] Differences in Covariance analysis between FOCE vs.
IMPMAP
Robert,
when trying your suggestion of using full omega instead of a band, I got the
message below with the standard compiled nm7.1.2.
Is there anything I can do?
0OMEGA HAS BLOCK FORM:
1
1 1
1 1 1
1 1 1 1
1 1 1 1 1
1 1 1 1 1 1
1 1 1 1 1 1 1
1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 2
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
0.1000E-01 0.6000E+01 0.8500E+02 0.1399E+01 0.5500E+00 0.2299E+01
0.1300E+00 0.4200E+02 0.9600E-01 0.3600E+02 0.4000E+01
0.6799E+01 0.6099E+01 0.1600E+02 0.1500E+01 0.4600E+05 0.6899E+00
0.6100E+02 0.1000E+02 -0.2000E-01
0INITIAL ESTIMATE OF OMEGA:
BLOCK SET NO. BLOCK
FIXED
1
NO
DIMENSION OF BLOCK EXCEEDS 8
From: [email protected] [mailto:[email protected]] On
Behalf Of Bauer, Robert
Sent: Tuesday, September 07, 2010 10:13 PM
To: Steingötter Andreas; nmusers
Subject: RE: [NMusers] Differences in Covariance analysis between FOCE vs.
IMPMAP
Andreas:
The IMP/IMPMAP method of standard error assessment for OMEGA band matrices may
be less reliable. I am presently investigating if there is a bug pertaining to
it, and if so, I shall have it fixed for the next version. Meanwhile, Monte
Carlo EM methods do quite well with full OMEGA matrices, so you may wish to
repeat the SAEM/IMP method with full OMEGA.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com