negative ETA shrinkage
Dear all,
I have found a negtive ETA shrinkage result in my model output. I did a
simple simulation with 1-compartement model via iv bolus administration, and
then refitted the simulated data with the same model and initial values. In
the NONMEM output (of NONMEM 7), I got ETAshrink(%): -2.0123E-01
-2.3271E-01. From the definition of ETA shrinkage: 1-SD(eta*)/omega, eta* is
the EBE estimated eta, there is no constraint preventing ETA shrinkage going
below zero. Could somebody give me an interpretation of negtive ETA
shrinkage?
Thanks in advance!
Maurice