negative ETA shrinkage

From: Chenguang Wang Date: September 05, 2010 technical Source: mail-archive.com
Dear all, I have found a negtive ETA shrinkage result in my model output. I did a simple simulation with 1-compartement model via iv bolus administration, and then refitted the simulated data with the same model and initial values. In the NONMEM output (of NONMEM 7), I got ETAshrink(%): -2.0123E-01 -2.3271E-01. From the definition of ETA shrinkage: 1-SD(eta*)/omega, eta* is the EBE estimated eta, there is no constraint preventing ETA shrinkage going below zero. Could somebody give me an interpretation of negtive ETA shrinkage? Thanks in advance! Maurice
Sep 05, 2010 Chenguang Wang negative ETA shrinkage
Sep 05, 2010 David Ternant Re: negative ETA shrinkage
Sep 05, 2010 Navin Goyal Re: negative ETA shrinkage
Sep 06, 2010 Robert Bauer RE: negative ETA shrinkage