Effect of placebo or drug to the baseline value
Dear NM users,
Many PK-PD articles reported the effect of placebo or drug to
the baseline value to be
1. Additive: Baseline- Placebo
effect - Drug effect
2. Proportiona: Baseline*(1- Placebo
effect)*(1-Drug effect)
However, I have not come across any literature with combined
approach of additive and proportional treatment effect e.g
(Baseline- Placebo effect)*(1-Drug effect)
Based on the initial dose-response relationship analysis using
longitudinal data, combined additive placebo effect and proportional drug
effect (Baseline- Placebo effect)*(1-Drug effect) resulted in lowest OFV,
good parameter
estimates and better Goodness of fit plots compared to the above 2 approaches.
I would like to seek your opinion on combined approach in PKPD modeling.
Thanking you,
Best Regards,
Venkatesh Pilla Reddy
PhD Fellow,
Dept. of Pharmacokinetics, Toxicology and Targeting,
University of Groningen,
Antonius Deusinglaan 1,
9713 AV Groningen, The Netherlands
Email: [email protected]