RE: simultaneous PK/PD

From: [email protected] [mailto:[email protected]] On Behalf Of Hauke Rühs Sent: Wednesday, June 23, 2010 8:54 AM To: [email protected] Subject: [NMusers] simultaneous PK/PD Dear NMusers, I want to combine my sequential PK and PD model to one simultaneous model. In both models I used an exponential error model (log-transformation). When I write the model as follows, NONMEM gives me this error message: 326 RANDOM VARIABLE IS DEFINED IN A NESTED IF STRUCTURE. Leaving out the condition C.GT.0 will also lead to errors. Is there another way to write this? Thanks Hauke $ERROR C1=(A(1)/V1) C3=A(3) IPRE=0 IF (M1H2.EQ.1) THEN IF (C1.GT.0) IPRE = LOG(C1) IRES = DV-IPRE W = EPS(1)*THETA(8) Y = IPRE+W ENDIF IF (M1H2.EQ.2) THEN IF (C3.GT.0) IPRE = LOG(C3) IRES = DV-IPRE W = EPS(1)*THETA(9) Y = IPRE+W ENDIF DEL = 0 IF(W.EQ.0) DEL = 1 IWRE = IRES/(W+DEL) $SIGMA 1 FIX ----------------------------- Hauke Rühs Apotheker Pharmazeutisches Institut - Klinische Pharmazie - An der Immenburg 4 53121 Bonn Tel: + 49-(0)228 73-5781 Fax: + 49-(0)228 73-9757 http://www.klinische-pharmazie.info/