Re: help on a minimization problem

Ethan, There are (at least) two kinds of evaluations/iterations you need to be aware of when using NONMEM. 1. The number of function evaluations which is a way of limiting the total work that NONMEM tries to make during estimation. It is determined by the estimation option MAXEVAL. 2. The number of iterations used by the differential equation solver when trying to make a step from one data record to the next. The problem you report is with the number of function evaluations. In NM7 you can specify a number larger than 10000 to ask NONMEM to do more work. The verbatim code trick you tried works with NMVI but not with NM7 to increase the number of differential equation solver iterations. Does anybody know how to get NM7 to try harder to solve differential equations? Nick Ethan Wu wrote: > Hi users, > I ran into this error with a analyis using PRED routine. > 0MINIMIZATION TERMINATED > DUE TO MAX. NO. OF FUNCTION EVALUATIONS EXCEEDED > NO. OF FUNCTION EVALUATIONS USED: 10093 > NO. OF SIG. DIGITS UNREPORTABLE > > I did find in previous discussion, people suggested to do by adding this under $PK > > " FIRST > " COMMON /PRCOMG/ IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " INTEGER IDUM1,IDUM2,IMAX,IDUM4,IDUM5 > " IMAX=100000 > but, when I added above below $PRED, it didn't work. > Any suggestion? Thanks. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford