RE: nm7 IMP method question
Desr Ethan,
It is my understanding that you should do an IMP step with EONLY=1 in order to
get an OFV to be used for hypothesis testing after a SAEM step, as the SAEM OFV
cannot be used for likelihood ratio tests. I think your problem is that the
first IMP step has converged (you asked for CTYPE=3), but in the second IMP
step you are not specifying any convergence criteria causing your OFV to wander
off (excuse the technical language).
Best wishes,
Joe
Joseph F Standing
Department of Pharmacy
Great Ormond Street Hospital for Children
London WC1N 3JH
Quoted reply history
________________________________________
From: [email protected] [[email protected]] On Behalf Of
Ethan Wu [[email protected]]
Sent: 12 May 2010 20:35
To: Sebastian Ueckert; nmusers
Subject: Re: [NMusers] nm7 IMP method question
Hi Sebastian,
sorry just reply now, somehow your email was spamed, I just recovered after
seeing other users reply to your email.
the reason I had another IMP step was, I remembered at nm7 workship, it was
suggested to run another IMP step for SE estimate.
The first IMP was done as
$EST METHOD=IMP INTERACTION NOABORT NITER=100 CTYPE=3 PRINT=1 SIGL=4
ISAMPLE=300
________________________________
From: Sebastian Ueckert <[email protected]>
To: nmusers <[email protected]>
Sent: Wed, May 12, 2010 11:08:09 AM
Subject: Re: [NMusers] nm7 IMP method question
Dear Ethan.
if you use the IMP method to estimate your parameters, you do not have to run a
second IMP step. The ESTEP is run for every iteration and if the OFV is stable
during the last iterations you can just use that. However the behavior you are
describing is strange. It could be related to different settings for both
steps. Can you please send the code for both $EST lines?
Best regards,
Sebastian
Sebastian Ueckert, MSc, PhD student
-----------------------------------------------
Pharmacometrics Research Group,
Department of Pharmaceutical Biosciences,
Uppsala University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
[email protected]<mailto:[email protected]>
-----------------------------------------------
Work: +46-(0)18-471 4437
On Wed, May 12, 2010 at 4:13 PM, Ethan Wu
<[email protected]<mailto:[email protected]>> wrote:
IACCEPT
********************************************************************************************************************
This message may contain confidential information. If you are not the intended
recipient please inform the
sender that you have received the message in error before deleting it.
Please do not disclose, copy or distribute information in this e-mail or take
any action in reliance on its contents:
to do so is strictly prohibited and may be unlawful.
Thank you for your co-operation.
NHSmail is the secure email and directory service available for all NHS staff
in England and Scotland
NHSmail is approved for exchanging patient data and other sensitive information
with NHSmail and GSI recipients
NHSmail provides an email address for your career in the NHS and can be
accessed anywhere
For more information and to find out how you can switch, visit
www.connectingforhealth.nhs.uk/nhsmail
********************************************************************************************************************