Re: simluation Tmax Cmax AUC

Hi, It looks like you are trying to derive the unknown values of KA, CL/F and V/F from the known values of Tmax, Cmax and AUC (probably obtained from a non compartmental analysis). If that is really the case, you will need to know the values of the half-life of elimination or the slope of elimination Ke to solve for Ka and V/F (the following solutions assume a one-compartment model with linear absorption and elimination): CL/F = Dose/AUC V/F = (CL/F)/Ke KA = - (1/tmax)*ln[ exp(-ke*tmax) - (Cmax*V)/(F*dose) ] If you don't know Ke, you will have to solve for V/F and Ka numerically, prior to your simulation. Sebastien yhb5442387 wrote: > Dear Nmuser: > > I would like to do a data simulation .The distributions of the drug population pharmaockinetics were assumed to be normal.But the profile that I have got is Tmax, Cmax,and AUC(the means and variances are already known),instead of Ka,CL,and V. What the $PK modification should I have to do in the model where the advan2 has been taken in the $subroutine. > > F=1. > > Any suggestion would be appreciated. > > Yours,ye hong bo > > -- > ??????????,????????????. > ????,????????????????????????.????????, > ??????