Update 4.10 to PDx-Pop for NONMEM 7 now available

Several new features have been added to PDx-Pop 4 in the new updated version, PDx-Pop 4.10: 1. A "Post-Processing" option button was added to add NONMEM runs not necessarily run within PDx-Pop to the Output Panel run-time log. This option runs the parameter and summary programs to add an entry for the run to the run-time log and creates a summary file if sufficient information is in the NONMEM result file. This option requires a NONMEM result file with a ".res" extension, the run data file, and a table file with the ".tab" extension to be placed in the current project directory. Pressing the "Post-Processing" button on the PDx-Pop Output tab allows selection of a result file from within the project directory from a browser window and initiates the post process. Once an entry occurs in the run-time log for the post-processed run, any of the PDx-Pop output features can be applied to the run (diagnostic plots, etc.) assuming that any additional table file required by the specific output features are also present in the current project directory. 2. Added "Refresh Log" button to the Output Panel. Occasionally (and unpredictably) the run-time log on the PDx-Pop Output tab either adds double entries or is entirely blank. The work-around has been to change to another project and then change back to the original project and the run-time log corrects itself. A "Refresh Log" button was added to the Output tab that rereads and redisplaya the run-time log without having to change project directories. 3. Extended the capabilities of the Model/Run tab "View Run-Time Plot" feature by allowing selection of the parameter to be plotted (instead of just the objective function). After the "View Run-Time Plot" button is pushed and the runno.ext file is created by the run, an additional window is displayed with a drop-down selection box for selecting the parameter is available. Select the parameter and then press the "Proceed" button on the window to begin plotting. 4. Created an alternative set of perl executable parameter and summary extraction programs that the user can implement that creates a summary file that contains the results for all of the estimation methods used in an individual run (instead of just the last method). Implementation is by renaming the current param.exe and summary.exe to param.last.exe and summary.last.exe, respectively. The new programs, param.mult.exe and summary.mult.exe, are then copied to the PDx-Pop installation directory and renamed to param.exe and summary.exe, respectively. The process can be reversed at any time by simply reversing the program file renaming process. 5. A new "Additional/Users Script" named "sp-plots.R" that creates spaghetti plots from the runno.tab file of the DV versus TIME for all individuals and the DV versus TAD for all individuals (if TAD is found in the .tab file). You can run the script by highlighting the desired run on the Output tab, checking the "Add'l/Users Scripts (S-Plus/R)" option and the clicking the "View Output" button. (The S-Plus version is named "sp-plots.ssc".) Note that there is a "timeunits" variable near the top of the script currently defined as "(hours)" that can manually be edited if the units are not hours and you can also manually edit the script to modify the y axis label. See the ReleaseNotes.pdf document found at ftp://ftp.globomaxnm.com/Public/pdxpop/PDx-Pop4.1/ for additional information. PDx-Pop 4.10 bug fixes: 1. Fixed bug in summary.exe program where %RSE and confidence intervals were not calculated for unsuccessfully terminated runs with $COV UNCONDITIONAL. 2. Fixed bug in the PDx-Pop control files wizards that gave a switched variance identifier ([p]/[a]) for the additive and proportional components of the additive plus proportional error model that could have resulted in calculation errors for the residual variance related to standard errors. 3. Fixed bug in PDx-Pop that failed to check and correct the run names for files with the .par, .eta, and .ext extensions with runs with Check Run Numbers checked. 4. Fixed bug in the param.exe program that limited the number of etas extracted from the .res file to 15 or less. Updating PDx-Pop 4.0 to PDx-Pop 4.10: 1. Copy to a backup folder any of the files with identical names in your PDx-Pop installation directory (if you installed PDx-Pop to the default directory, the directory is c:\pdxpop4) as those found in the ftp folder (ftp://ftp.globomaxnm.com/Public/pdxpop/PDx-Pop4.1/). 2. Download all the files found at ftp://ftp.globomaxnm.com/Public/pdxpop/PDx-Pop4.1/ to your PDx-Pop 4 installation directory. 3. Start the program and you are now ready to use PDx-Pop 4.10. William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 6031 University Blvd., Suite 300 Ellicott City, MD 21043 Office 215-616-8699 Cell 301-467-8635 [email protected]