WFN for NONMEM 7 - version 702

Hi, I have uploaded a new version of Wings for NONMEM (version 702) to http://wfn.sourceforge.net Version Notes 14 February 2010 Version 702/616 Users of Monolix can create a model building table from Monolix projects with the mlxmbt command. The format of the output is the same as that used with the nmmbt command. Note: When Monolix is asked to compute the log likelihood it adds a constant term equal to Obs*ln(2*pi) that is not added by NONMEM. The Monolix derived “Obj” value reported by the mlxmbt command can be converted to the equivalent value computed by NONMEM by subtracting Obs*ln(2*pi) from the Monolix value. Unfortunately Monolix does not save the number of observations (Obs) so this cannot currently be done automatically by mlxmbt. WFN Version 702 and 616 have an improved model building summary table format. The nmmbt.txt file sequence of column headings is more likely to be presented in a useful format when multiple runs are combined. The WFN extended control stream format supports the use of $OMEGA parameter names when MU referencing is used. When the MU index is the same as the corresponding ETA used for that MU then MU referencing can be coded without counting ETA values e.g. $THETA 10 ; POP_CL $OMEGA 0.5 ; PPV_CL [this corresponds to eta(1)] $PK MU_1=LOG(POP_CL) CL=EXP(MU_1+ETA(1)) Can be written: $PK MU_PPV_CL=LOG(POP_CL) CL=EXP(MU_PPV_CL+PPV_CL) Note: the use of parameter names for MU referencing is optional. If you use the $OMEGA parameter name then WFN will replace it with a suitable numeric value for NM-TRAN to process otherwise the code will not be changed by WFN. A bug has been fixed for reporting the estimation method. Version 701 reported FOCE when it should have been FOCEI. Please let me know if/when you discover bugs. Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +64 21 46 23 53 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford