RE: EHC modelling

Hi Joan You may find the following papers useful. Jiao Z, Ding JJ, Shen J, Liang HQ, Zhong LJ, Wang Y, Zhong MK and Lu WY (2008) Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9. Br J Clin Pharmacol 65:893-907. Yau W-P, Vathsala A, Lou H-X, Zhou S and Chan E (2009) Mechanism-Based Enterohepatic Circulation Model of Mycophenolic Acid and Its Glucuronide Metabolite: Assessment of Impact of Cyclosporine Dose in Asian Renal Transplant Patients. J Clin Pharmacol 49:684-699. Also, please note that gallbladder is not getting fully emptied when it contracts and the emptying process is not abrupt. In addition, there are cases where a part of metabolite may return to the parent form (deconjugated) when it reaches the small intestine. Regards Masoud