transit model after IV dose?

From: Ann Rigby-Jones Date: January 20, 2010 technical Source: mail-archive.com
Dear All I am interested in trying a transit model in an attempt to better describe early drug concentrations following intravenous injection (1 minute and 10 minute infusions) of a sedative-hypnotic drug. I found some examples of transit model control streams following oral administration but I wondered if someone might be able to help me with an example following IV dosing, as I'm currently unsure of the implementation in NONMEM? I'd be very grateful for any advice you could offer :) With thanks and all best wishes Ann _______________________________________________________________________ Ann Rigby-Jones PhD MRSC Research Fellow in Pharmacokinetics & Pharmacodynamics Peninsula College of Medicine & Dentistry Plymouth England, UK _______________________________________________________________________