transit model after IV dose?
Dear All
I am interested in trying a transit model in an attempt to better describe
early drug concentrations following intravenous injection (1 minute and 10
minute infusions) of a sedative-hypnotic drug. I found some examples of
transit model control streams following oral administration but I wondered if
someone might be able to help me with an example following IV dosing, as I'm
currently unsure of the implementation in NONMEM?
I'd be very grateful for any advice you could offer :)
With thanks and all best wishes
Ann
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Ann Rigby-Jones PhD MRSC
Research Fellow in Pharmacokinetics & Pharmacodynamics
Peninsula College of Medicine & Dentistry
Plymouth
England, UK
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